Isao Date Selected Research

Ischemic Stroke

12/2021	The Japan Neurosurgical Database: Statistics Update 2018 and 2019.
1/2018	Electrical Stimulation Enhances Migratory Ability of Transplanted Bone Marrow Stromal Cells in a Rodent Ischemic Stroke Model.
8/2017	Mesenchymal Stem Cell Therapy for Ischemic Stroke.
1/2015	Intra-Arterial Transplantation of Allogeneic Mesenchymal Stem Cells Mounts Neuroprotective Effects in a Transient Ischemic Stroke Model in Rats: Analyses of Therapeutic Time Window and Its Mechanisms.
1/2014	Therapeutic outcomes of transplantation of amniotic fluid-derived stem cells in experimental ischemic stroke.
1/2012	The therapeutic potential of human umbilical cord blood transplantation for neonatal hypoxic-ischemic brain injury and ischemic stroke.
11/2009	Electrical stimulation of the cerebral cortex exerts antiapoptotic, angiogenic, and anti-inflammatory effects in ischemic stroke rats through phosphoinositide 3-kinase/Akt signaling pathway.

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Isao Date Research Topics

Disease

42	Neoplasms (Cancer) 04/2022 - 08/2004
30	Parkinson Disease (Parkinson's Disease) 07/2021 - 08/2001
21	Glioma (Gliomas) 12/2021 - 03/2005
13	Glioblastoma (Glioblastoma Multiforme) 01/2020 - 09/2003
13	Stroke (Strokes) 12/2019 - 02/2004
11	Aneurysm (Aneurysms) 01/2022 - 02/2009
9	Brain Ischemia (Cerebral Ischemia) 01/2014 - 02/2004
8	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 01/2022 - 05/2004
7	Ischemic Stroke 12/2021 - 11/2009
7	Infarction (Infarctions) 10/2020 - 12/2003
7	Brain Edema (Cerebral Edema) 02/2019 - 12/2004
6	Pain (Aches) 10/2021 - 08/2005
6	Intracranial Aneurysm (Cerebral Aneurysm) 07/2021 - 04/2007
6	Trigeminal Neuralgia (Tic Douloureux) 01/2021 - 01/2007
6	Brain Neoplasms (Brain Tumor) 07/2020 - 10/2005
6	Traumatic Brain Injuries (Traumatic Brain Injury) 02/2019 - 09/2012
6	Intracranial Vasospasm 11/2016 - 07/2007
6	Ischemia 10/2013 - 02/2004
6	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 05/2011 - 12/2003
5	Brain Injuries (Brain Injury) 01/2022 - 01/2012
5	Hemifacial Spasm 01/2021 - 08/2006
5	Central Nervous System Vascular Malformations (Dural Arteriovenous Fistula) 10/2020 - 09/2007
5	Epilepsy (Aura) 07/2017 - 05/2009
5	Hematoma 08/2014 - 06/2007
4	Disease Progression 01/2021 - 05/2011
4	Residual Neoplasm 08/2020 - 01/2006
4	Central Nervous System Diseases (CNS Diseases) 01/2020 - 01/2014
4	Nervous System Diseases (Neurological Disorders) 01/2014 - 03/2004
3	Aortic Dissection 01/2022 - 12/2009
3	Edema (Dropsy) 01/2021 - 12/2004
3	Wounds and Injuries (Trauma) 07/2020 - 01/2019
3	Hypoxia (Hypoxemia) 06/2020 - 01/2008
3	Inflammation (Inflammations) 12/2019 - 01/2012
3	Pituitary Neoplasms (Pituitary Adenoma) 01/2019 - 06/2016
3	Cavernous Hemangioma (Cavernous Angioma) 01/2016 - 01/2010
3	Meningioma (Meningiomas) 02/2014 - 12/2004
3	Seizures (Absence Seizure) 11/2013 - 10/2009
3	Fistula 12/2011 - 10/2004
2	Tuberous Sclerosis (Bourneville's Disease) 06/2022 - 10/2005
2	Dyskinesias (Dyskinesia) 07/2021 - 06/2009
2	Tremor (Tremors) 07/2021 - 08/2017
2	Arteriovenous Fistula 12/2020 - 04/2011
2	Neoplasm Metastasis (Metastasis) 08/2020 - 09/2003
2	Infections 07/2020 - 01/2008
2	Paresis (Hemiparesis) 01/2020 - 01/2011
2	Treatment-Resistant Depressive Disorder 01/2020 - 01/2019
2	Cysts 12/2019 - 01/2014
2	Moyamoya Disease (Moya-Moya Disease) 12/2019 - 11/2005
2	Ependymoma 09/2019 - 12/2018
2	Ruptured Aneurysm 01/2019 - 09/2012
2	Astrocytoma (Pilocytic Astrocytoma) 08/2018 - 10/2005

Drug/Important Bio-Agent (IBA)

14	Neuroprotective AgentsIBA 01/2021 - 03/2004
14	Proteins (Proteins, Gene)FDA Link 08/2019 - 03/2005
13	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019 - 03/2004
7	Therapeutic UsesIBA 10/2013 - 01/2008
6	Bevacizumab (Avastin)FDA Link 01/2021 - 06/2013
6	HMGB1 Protein (HMG1)IBA 12/2019 - 05/2011
6	IntegrinsIBA 10/2015 - 01/2012
6	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 01/2008 - 08/2001
5	Monoclonal AntibodiesIBA 02/2019 - 05/2011
5	CilengitideIBA 04/2014 - 01/2012
5	Nerve Growth Factors (Neurotrophins)IBA 01/2011 - 08/2001
4	Pharmaceutical PreparationsIBA 05/2022 - 04/2016
4	Biological ProductsIBA 01/2021 - 01/2009
4	Brain-Derived Neurotrophic Factor (BDNF)IBA 07/2017 - 02/2004
4	Dopamine (Intropin)FDA LinkGeneric 01/2017 - 04/2003
4	Capsules (Microcapsules)IBA 01/2011 - 04/2003
3	CytokinesIBA 01/2016 - 02/2004
3	Erythropoietin FDA Link 03/2013 - 02/2009
2	trans-sodium crocetinate (crocetin)IBA 06/2022 - 10/2005
2	Tissue Plasminogen Activator (Alteplase)FDA Link 12/2021 - 10/2008
2	Temozolomide (Temodar)FDA LinkGeneric 12/2021 - 01/2019
2	Methotrexate (Mexate)FDA LinkGeneric 07/2020 - 12/2014
2	Messenger RNA (mRNA)IBA 01/2019 - 11/2005
2	Anticonvulsants (Antiepileptic Drugs)IBA 07/2017 - 11/2013
2	ranimustineIBA 05/2017 - 01/2006
2	Carboplatin (JM8)FDA LinkGeneric 05/2017 - 01/2006
2	Etoposide (VP 16)FDA LinkGeneric 05/2017 - 01/2006

Therapy/Procedure

52	Therapeutics 01/2022 - 08/2003
17	Transplantation 01/2021 - 04/2003
10	Microvascular Decompression Surgery 01/2021 - 08/2006
9	Drug Therapy (Chemotherapy) 12/2021 - 01/2006
9	Deep Brain Stimulation 07/2021 - 10/2004
8	Craniotomy 04/2021 - 07/2006
8	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2020 - 01/2005
8	Cell Transplantation 01/2015 - 08/2003
7	Radiotherapy 08/2020 - 08/2005
6	Stents 01/2020 - 11/2012
5	Catheters 12/2019 - 10/2004
4	Electrodes (Electrode) 05/2018 - 01/2011
3	Decompression 07/2021 - 02/2009
3	Laminoplasty 01/2021 - 01/2011
3	Laminectomy 01/2021 - 01/2010
3	Spinal Cord Stimulation 01/2020 - 01/2012
3	Endovascular Procedures 07/2013 - 01/2011
2	Chemoradiotherapy 12/2021 - 01/2012
2	Surgical Instruments (Clip) 07/2021 - 01/2020
2	Neurosurgical Procedures 08/2020 - 08/2003
2	Length of Stay 07/2020 - 01/2019
2	Sutures (Suture) 07/2020 - 12/2003